Through a comprehensive range of solutions, efficient end-to-end services and connections with international regulatory agencies, we help build your program with a sound regulatory strategy, optimal trial design and compliance with global submission requirements.

AACR 2022 -- Bladder cancer (BC) is the thirteenth leading cause of cancer-related deaths. Five checkpoint immunotherapies that target the PD-1/PD-L1 axis are FDA approved, and gene- and protein-based approaches are helping to identify new combination treatment strategies for therapeutic intervention.

AACR 2022 -- T cells engineered to express Chimeric Antigen Receptors (CARs) through transduction with a lentiviral vector represent an effective strategy to specifically eliminate cancerous cells from a patient. Anti-CD19 single chain variable fragment (ScFv) is the extracellular, antigen-binding domain.

AACR 2022 -- Labcorp has employed 3D model systems co-developed with zPREDICTA to create preclinical models to address the increasing relevance of 3D in vitro models. These organ-specific models support tumor cell growth and mimic the composition and architecture of both solid tumors and hematological malignancies.

AACR 2022 -- Syngeneic mouse tumor models are widely used to demonstrate activity of novel anti-cancer immunotherapies. RM-1 is a murine prostate cancer cell line derived from a Ras/Myc-induced prostate cancer that grows aggressively, is nonimmunogenic and androgen independent.

AACR 2022 -- In the preclinical oncology setting, the B16-F10 syngeneic melanoma model is commonly used but is highly refractory to most immunomodulators, limiting the applicability of this model.

The Delivery Director role is a key component of the Labcorp Drug Development Operating Model for clinical trials. One is assigned to each trial and is a senior leader who improves the delivery through experience, insight and connections within the business.

With an integrated, global safety team of over 2,700 across 20 delivery centers, we provide end-to-end safety solutions that span the entire product life cycle of drugs, medical devices, combination products and vaccines from clinical phases through commercialization.