Cardiac single-cell degeneration in common marmosets (Callithrix jacchus)

ESVP/ESTP/ECVP Congress 2024 -- In the last two decades, common marmosets (Callithrix jacchus) have been more frequently used in preclinical toxicity studies due to their physiological similarities with humans. For instance, several surface receptors on marmoset lymphocytes are cross-reactive with monoclonal antibodies against the corresponding human variant and the hepatic metabolism mimics the human pathways more closely than other nonhuman primates (NHPs) (Han et al., 2022). Nevertheless, marmosets differ from macaques regarding spontaneous diseases and background pathology and only few descriptions are available in the literature that might complicate the interpretation of findings in this species. Thus far, myocardial degeneration has been described by Okazaki et al. as spontaneous background pathology in minimal to slight magnitude in single animals (5/59). Necrosis in the heart is described very rarely in the literature (2/597 animals in David et al., 2009).

Mysterious lesion in the brain of a cynomolgus monkey (Macaca fascicularis): What’s your diagnosis?

ESVP/ESTP/ECVP Congress 2024 -- In recent years, the development of new drug modalities has underlined the importance of nonhuman primates in biomedical research. Simultaneously, the central nervous system (CNS) has gained importance as a target for different drug modalities including gene therapeutics (Gao et al., 2024). Therewith, the CNS is often closely examined and a popular subject of lively discussions on the cause and significance of unusual findings. Herewith, the authors describe an exceptional finding in the brain of a cynomolgus monkey (Macaca fascicularis) of unknown etiology.

How a patient with dermatomyositis adjusted to a life without the sun

For Cindy Singleton, an IT product manager at Labcorp, being diagnosed with a rare autoimmune disease forever changed the way she lives. "The most difficult thing is not being able to go out in the sun," she said. "I was a very outdoorsy person before; I used to show horses. Now I stay inside, especially between 10 a.m. and 4 p.m." Singleton first started noticing symptoms about six years ago. She developed Raynaud's syndrome, which caused her hands to turn blue and lose circulation. Soon after, an itchy rash appeared all over her body. For months, her doctor thought it was just dermatitis. But when Singleton visited her dermatologist for her annual check-up, the dermatologist recognized the distinctive rashes as a sign of something more serious. A biopsy confirmed dermatomyositis, and Singleton was prescribed creams to help manage the itching."I'd never heard of it before," Singleton said. "It was all new to me."  

“It was pretty much hell for a year”: A Labcorp employee’s journey with dermatomyositis

When a rash first appeared on Donna Carter's forehead in the summer of 2021, she thought little of it. Assuming it was just a reaction to a new skin cream, Carter consulted a telehealth doctor who prescribed some topical treatments. But as weeks passed, the rash persisted. 

Planning for price transparency regulations: How health system labs play a role

Bryan Vaughn, senior vice president of health systems at Labcorp, shares his perspective on price transparency regulations and the impact health systems labs play in these changes.

Discovery Oncology: Patient-derived xenograft models

Improve your therapeutic efficacy predictions with Labcorp's PDX models

Leveraging lab data to combat diabetes and chronic kidney disease

Social determinants of health impact an estimated 80%-90% of patient outcomes. Learn how you can leverage lab data to enhance population health, see hot spots that need attention and target them through preventive and gaps in care programs

Nonclinical Solutions - Toxicology

Propel your development program with Labcorp's comprehensive toxicology solutions. Toxicology plays a critical role in assessing and mitigating potential adverse effects, ensuring regulatory compliance, and understanding toxicity mechanisms to optimize drug safety and efficacy. To enhance the therapeutic potential of your drug candidate while minimizing patient risk, partnering with a laboratory that offers extensive capabilities and expertise is essential.

Three best practices to cultivate healthier, thriving communities

Managed care organizations are no strangers to alarming statistics about barriers to healthcare access. Nevertheless, the numbers are still astounding when laid out next to each other—especially for those residing in the rural United States. We can help cultivate healthier, thriving communities with the best practices below.