September 3, 2024

Labcorp to Speak at the Baird 2024 Global Healthcare Conference

BURLINGTON, N.C. , Sept. 3, 2024 /PRNewswire/ --  Labcorp (NYSE: LH), a global leader of innovative and comprehensive laboratory services, announced today that members of the executive management team will participate in a presentation at the Baird 2024 Global Healthcare Conference on Tuesday,

Interface Facilitation Terms and Conditions

August 28, 2024

Cardiac single-cell degeneration in common marmosets (Callithrix jacchus)

ESVP/ESTP/ECVP Congress 2024 -- In the last two decades, common marmosets (Callithrix jacchus) have been more frequently used in preclinical toxicity studies due to their physiological similarities with humans. For instance, several surface receptors on marmoset lymphocytes are cross-reactive with monoclonal antibodies against the corresponding human variant and the hepatic metabolism mimics the human pathways more closely than other nonhuman primates (NHPs) (Han et al., 2022). Nevertheless, marmosets differ from macaques regarding spontaneous diseases and background pathology and only few descriptions are available in the literature that might complicate the interpretation of findings in this species. Thus far, myocardial degeneration has been described by Okazaki et al. as spontaneous background pathology in minimal to slight magnitude in single animals (5/59). Necrosis in the heart is described very rarely in the literature (2/597 animals in David et al., 2009).
August 28, 2024

Mysterious lesion in the brain of a cynomolgus monkey (Macaca fascicularis): What’s your diagnosis?

ESVP/ESTP/ECVP Congress 2024 -- In recent years, the development of new drug modalities has underlined the importance of nonhuman primates in biomedical research. Simultaneously, the central nervous system (CNS) has gained importance as a target for different drug modalities including gene therapeutics (Gao et al., 2024). Therewith, the CNS is often closely examined and a popular subject of lively discussions on the cause and significance of unusual findings. Herewith, the authors describe an exceptional finding in the brain of a cynomolgus monkey (Macaca fascicularis) of unknown etiology.
<span>How a patient with dermatomyositis adjusted to a life without the sun</span>
August 28, 2024

How a patient with dermatomyositis adjusted to a life without the sun

For Cindy Singleton, an IT product manager at Labcorp, being diagnosed with a rare autoimmune disease forever changed the way she lives. "The most difficult thing is not being able to go out in the sun," she said. "I was a very outdoorsy person before; I used to show horses. Now I stay inside, especially between 10 a.m. and 4 p.m." Singleton first started noticing symptoms about six years ago. She developed Raynaud's syndrome, which caused her hands to turn blue and lose circulation. Soon after, an itchy rash appeared all over her body. For months, her doctor thought it was just dermatitis. But when Singleton visited her dermatologist for her annual check-up, the dermatologist recognized the distinctive rashes as a sign of something more serious. A biopsy confirmed dermatomyositis, and Singleton was prescribed creams to help manage the itching."I'd never heard of it before," Singleton said. "It was all new to me."