February 1, 2024
Pancreatic cancer, particularly pancreatic ductal adenocarcinoma (PDAC), stands as a formidable global health challenge with a projected incidence of 18.6 per 100,000 by 2050. Surgical resection, the potential cure, is hindered by late-stage diagnoses, limiting viable candidates. Accounting for 85% of pancreatic cancer cases, PDAC often eludes early detection due to its retroperitoneal location, resulting in dismal 5-year survival rates not surpassing 10%. Other challenges include the tumor’s aggressive nature, patient frailty and pervasive resistance to therapies. Overcoming these challenges demands innovative approaches and BxPC-3, a human PDAC model, emerges as a valuable tool for in vitro and in vivo testing of novel therapeutic interventions to improve outcomes.
