Comprehensive Genomic Testing: Tissue Stewardship and Best Practices

Comprehensive genomic profiling (CGP) plays a key role in precision medicine as it enables simultaneous identification of multiple tumor biomarkers to guide cancer diagnosis, therapy selection, and prognostication. Thus, tissue stewardship for successful CGP is critical. This paper provides an overview of genomic testing methodologies and offers guidelines on best practices for tissue stewardship and pre-analytic practices to enable successful CGP with efficient turnaround times.