Human Immunodeficiency Virus 1 (HIV-1) Trofile® (Monogram® Coreceptor Tropism)

TEST: 553100
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Synonyms

  • CCR5
  • Chemokine Coreceptor Tropism Trofile®
  • CXCR4

Expected Turnaround Time

27 - 35 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Related Documents

For more information, please view the literature below.

HIV Specimen Collection Guide

HIV-1 Lifecycle, Drugs, and Susceptibility Assays

Supporting Individualized HIV Treatment Decisions

Specimen Requirements

Specimen

Plasma, frozen

Volume

3 mL

Container

Lavender-top (EDTA) or plasma preparation tube (PPT™)

Collection

Collect specimen in two lavender-top (EDTA) tubes or two PPT™ tubes. Do not use green-top (heparin) tubes. Centrifuge specimen within six hours of collection. Transfer plasma to one or more polypropylene screw-capped tube(s) (not "pop-top" or "snap-cap"), and freeze. Ship specimen frozen. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.

Storage Instructions

Freeze

Causes for Rejection

PPT™ not centrifuged; insufficient volume; heparinized plasma; nonfrozen specimen

Test Details

Use

Detect HIV-1 coreceptor tropism; determine eligibility for CCR5 antagonist therapy such as maraviroc (Selzentry®)

Limitations

This procedure should be used for patients with documented HIV-1 infection and viral loads ≥1000 copies/mL.

This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.

Methodology

Polymerase chain reaction (PCR) amplification and viral culture. Samples are forwarded to Monogram Biosciences® for testing, reporting, and billing. Trofile® is a trademark of Monogram Biosciences®.

References

Whitcomb JM, Huang W, Fransen S, et al. Development and characterization of a novel single-cycle recombinant-virus assay to determine human immunodeficiency virus type 1 coreceptor tropism. Antimicrob Agents Chemother. 2007; 51(2):566-575.17116663

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
553100 Trofile(R) 829632 Trofile(R) PDF 51969-4
553100 Trofile(R) 829666 Tropotype: 50790-5
553100 Trofile(R) 829633 Trofile(R) 57182-8
553100 Trofile(R) 829634 Trofile(R) Interpretation 77202-0
553100 Trofile(R) 829635 Trofile(R) Methodology 49549-9
553100 Trofile(R) 829636 Trofile(R) References 75608-0

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