Forced degradation is defined as the intentional degradation of a biotherapeutic to an appropriate extent by means of various stressing agents. The overall aim of such forced degradation (also known as stress studies) is to understand how a biotherapeutic may undergo degradation, whether this occurs during or following manufacture. More specifically, forced degradation aims to accelerate the chemical and physical changes of a biopharmaceutical molecule in order to determine the mechanisms of degradation depending on the various stresses applied to it.

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