APA 2024 -- Antibody-drug conjugates (ADCs) are an increasingly popular approach to selectively deliver a drug, the “payload”, to target cells or tissues with minimal off-target effects. A proprietary ADC with a self-immolative linker is being investigated. Three bioanalytical assays in nonhuman primate (NHP) plasma are to be developed: Total antibody, free payload and conjugated payload. 

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