Trofile® Assays Determine Viral Tropism
More than 100,000 samples have been tested using Labcorp’s Trofile® assays. All investigational trials of coreceptor antagonists have used Trofile® in their clinical development. Trofile® has been shown to be accurate, precise, sensitive, reproducible and robust in the measurement of HIV-1 coreceptor tropism.
Department of Health and Human Services (DHHS) and Infectious Diseases Society of America (IDSA) guidelines recommend that a coreceptor tropism test be performed whenever the use of a CCR5 antagonist is being considered for HIV treatment.1,2 Coreceptor tropism testing might also be considered for patients who exhibit virologic failure while taking a CCR5 inhibitor.
Labcorp offers two assays for determining tropism for patients based on viral load: one for patients with viremia and the other for patients with viral suppression.