Multiple Sclerosis (MS) Profile With Myelin Basic Protein, Cerebrospinal Fluid

TEST: 123390
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CPT: 82040; 82042; 82784(x2); 83873; 83916
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Synonyms

  • MS Profile

Test Includes

IgG and albumin quantitation in both serum and spinal fluid samples; CSF IgG:CSF albumin ratio; CSF IgG index; CSF IgG synthesis rate; myelin basic protein (CSF); oligoclonal banding

Expected Turnaround Time

4 - 9 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Related Documents

Specimen Requirements

Specimen

Serum and cerebrospinal fluid (CSF), collected at the same time

Volume

2 mL serum and 2.5 mL CSF

Minimum Volume

0.8 mL serum and 1.4 mL CSF

Sample Requirements for Multiple Sclerosis Profile

Profile Components

CSF Preferred

CSF Minimum

Serum Preferred

Serum Minimum

Notes

*IgG synthesis rate and IgG:albumin ratio (CSF) within the multiple sclerosis profile utilize the same IgG and albumin (CSF and serum) results from the IgG index for calculations; therefore, no additional sample is required.

Myelin basic protein (MBP)

1 mL

0.8 mL

N/A

N/A

Oligoclonal banding

0.5 mL

0.1 mL

0.5 mL

0.1 mL

Serum and CSF must be collected at the same time.

IgG index*

1 mL

0.5 mL

1.5 mL

0.7 mL

Includes IgG and albumin on CSF and serum

Total sample required

2.5 mL

1.4 mL

2 mL

0.8 mL

Container

Plastic transport tubes

Collection

Collect serum and CSF at the same time. Avoid contaminating CSF with blood. Centrifuge CSF at 1500xg for 20 minutes and place the supernatant into separate tubes. Ensure residual fibrin and cellular matter have been removed.

Storage Instructions

Room temperature

Stability Requirements

Temperature

Period

Room temperature

14 days

Refrigerated

14 days

Frozen

14 days

Freeze/thaw cycles

Stable x2

Causes for Rejection

Plasma instead of serum specimen; serum and CSF not collected within eight hours of each other; lipemic, hemolyzed, or icteric CSF specimen

Test Details

Use

Adjunct in aiding clinical diagnosis of multiple sclerosis

Limitations

Results for this test are for research purposes only by the assay's manufacturer. The performance characteristics of this product have not been established. Results should not be used as a diagnostic procedure without confirmation of the diagnosis by another medically established diagnostic product or procedure.

Methodology

MBP: enzyme-linked immunosorbent assay (ELISA); oligoclonal banding: IEF; CSF IgG, CSF albumin, and serum IgG: immunologic; serum albumin: spectrophotometry; synthesis rate, ratio, and index by calculation

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
123390 MS Profile+MBP, CSF 012212 IgG, Quant, CSF mg/dL 2464-6
123390 MS Profile+MBP, CSF 012230 Albumin, CSF mg/dL 1746-7
123390 MS Profile+MBP, CSF 001081 Albumin g/dL 1751-7
123390 MS Profile+MBP, CSF 001776 Immunoglobulin G, Qn, Serum mg/dL 2465-3
123390 MS Profile+MBP, CSF 160311 IgG/Alb Ratio, CSF 2470-3
123390 MS Profile+MBP, CSF 101124 CSF IgG Index 14117-6
123390 MS Profile+MBP, CSF 085937 IgG, Syn Rate,CSF mg/day 14116-8
123390 MS Profile+MBP, CSF 123378 Myelin Basic Protein, CSF ng/mL 2638-5
123390 MS Profile+MBP, CSF 111237 Oligoclonal Bands N/A
123390 MS Profile+MBP, CSF 111666 Oligoclonal Bands 48668-8
123390 MS Profile+MBP, CSF 120173 CSF/Serum Alb. Index 1756-6

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CPT Statement/Profile Statement

The LOINC® codes are copyright © 1994-2021, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf