Apolipoprotein A-1

TEST: 016873
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CPT: 82172
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Synonyms

  • A-1 Apolipoprotein
  • Alpha-Apolipoprotein

Special Instructions

State patient's sex on the test request form.

Expected Turnaround Time

1 - 2 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Related Documents

For more information, please view the literature below.

Spanning the Continuum of Cardiovascular Care

Specimen Requirements

Specimen

Serum (preferred) or plasma

Volume

2 mL

Container

Red-top tube, gel-barrier tube, green-top (heparin) tube, or lavender-top (EDTA) tube

Collection

Separate serum or plasma from cells. Transfer specimen to a plastic transport tube.

Storage Instructions

Maintain specimen at room temperature.

Stability Requirements

Temperature

Period

Room temperature

14 days

Refrigerated

14 days

Frozen

14 days

Freeze/thaw cycles

Stable x3

Patient Preparation

Patient must be fasting 12 to 14 hours.

Causes for Rejection

Specimen from nonfasting patient

Test Details

Use

Apo A-1 comprises 60% to 70% of the protein content of HDL. Apo A-1 serves as an activator of LCAT which is involved in the transport of cholesterol from peripheral tissues to the liver where it is degraded. Decreased serum HDL cholesterol levels have been reported to correlate with increased risk of coronary artery disease (CAD); however, Apo A-1 has been suggested as a better discrimination of CAD than HDL.1 Apo A-1 levels also correlate with survival rates or risk factors for patients with myocardial infarction and peripheral vascular disease. Measurement of Apo A-1 may also aid in the diagnosis of Tangier disease (absence of alpha-lipoprotein).

Methodology

Immunologic

Reference Interval

See table.

Male (mg/dL)

0 to 14 d

62−91

15 d to 11 m

53−175

1 to 5 y

80−164

6 to 12 y

107−175

>12 y

101−178

Female (mg/dL)

0 to 14 d

71−97

15 d to 11 m

53−175

1 to 5 y

80−164

6 to 80 y

116−209

>80 y

114−214

Footnotes

1. Maciejko JJ, Holmes DR, Kottke BA, et al. Apolipoprotein A-1 as a marker of angiographically assessed coronary-artery disease. N Engl J Med. 1983; 309(7):385-389. 6410239

References

Colantonio DA, Kyriakopoulou L, Chan MK, et al. Closing the gaps in pediatric laboratory reference intervals: A CALIPER database of 40 biochemical markers in a healthy and multiethnic population of children. Clin Chem. 2012 May; 58(5):854-868. 22371482

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
016873 Apolipoprotein A-1 1869-7 016873 Apolipoprotein A-1 mg/dL 1869-7

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