ACT 2024 -- Microcystic-like epithelial changes (MECs) in the cornea (keratopathy) are a known ocular toxicity risk of antibody-drug conjugates with microtubulin-acting payloads that generally manifest unrelated to antibody target and occur in the absence of corneal target expression. Dutch-Belted rabbits have been utilized for ocular toxicity studies to replicate and investigate presentation, onset and explore prophylactic techniques to mitigate this corneal finding. Here we evaluate if mice are a useful preclinical model for predicting keratopathy and compare the onset, severity and characterization of MECs in rabbits to mice using confocal microscopy and histopathological evaluation.

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