Management of HIV-1 Treatment Regimens When There Is Virologic Suppression

GenoSure Archive® was designed to provide HIV-1 anti-retroviral (ARV) resistance data when a patient’s viral load is suppressed or too low for standard resistance testing.  The assay interrogates the viral archive in  peripheral blood mononuclear cells (PBMCs) using next-generation sequencing (NGS) to identify archived mutations and to then assign susceptibility calls of sensitive, resistant and resistance possible based on those mutations.  Drug classes evaluated by GenoSure Archive® include nucleoside reverse transcriptase inhibitors (NRTIs), non-nucleoside reverse transcriptase inhibitors (NNRTIs), integrase inhibitors (INIs) and protease inhibitors (PIs).

Trofile® DNA utilizes cell-associated viral DNA to determine tropism in patients with viral loads less than 1000 copies/mL. The assay incorporates the single cycle recombinant phenotype of Trofile® to cell-associated viral DNA. Trofile® DNA is a patient selection assay which identifies patients appropriate for use of a CCR5 antagonist for HIV-1 treatment when the viral load is < 1000 copies/mL.